We examined survival and cause-specific mortality of 37 adult coyotes using radio telemetry in central Mississippi during 1993–1997. Annual survival did not differ between sexes or across years, but did among seasons. Mean survival probabilities (sexes combined) were greater during pup-rearing (0.98) than breeding (0.84) or winter (0.89). Harvest by sport hunters was the most prevalent of known mortalities. Our findings indicate that southeastern coyotes have greater survival probabilities than populations in other regions due to lower harvest levels.